Angiogenesis is the growth of blood vessels from the existing vasculature. The field of angiogenesis has grown enormously in the past 30 years, with only 40 papers published in 1980 and nearly 6000 in 2010. Why has there been this explosive growth in angiogenesis research? Angiogenic therapies provide a potential to conquer cancer, heart diseases, and more than 70 of life
Table of Contents
Overview of Angiogenesis
Angiogenesis Assays
Regulation: Metabolic Factors
Regulation: Mechanical Factors
Glossary
References
Author Biographies
About the Author(s)
Thomas Adair, University of Mississippi Medical Center
Dr. Thomas H. Adair is a scientist and teacher at the University of Mississippi Medical Center, a professor of physiology and biophysics, and the director of Angiogenesis Research Laboratories. He received a Ph.D. degree from the University of Texas Medical Branch and did postdoctoral training with Arthur C. Guyton. He pioneered work in the field of angiogenesis showing that oxygen is a major control element in growth regulation of the vascular system and was the first to prove that exercise stimulates production of vascular endothelial growth factor, a key proangiogenic substance. He has published more than 150 papers and reviews in the field over the past 30 years and has been a consultant for various governmental agencies. He is also an award-winning teacher, served on the National Board of Medical Examiners, and has authored or contributed to numerous physiology textbooks and review books.
Jean-Pierre Montani, University of Mississippi Medical Center
Dr. Jean-Pierre Montani is a professor and the head of the Division of Physiology in the Department of Medicine at the University of Fribourg, Switzerland. He received an M.D. degree from the University of Geneva and devoted many years in Switzerland to clinical training in internal medicine. His interests in mathematical modeling and computer simulation led to a 13-year tenure in the United States under the mentorship of Arthur C. Guyton. His research has focused on the dynamics of cardiovascular and metabolic control systems using both experimental animals and mathematical modeling. He is an award-winning teacher and has lectured extensively on all aspects of physiology throughout Europe and the United States. He has published more than 150 papers and reviews during the past 30 years and has been a consultant for various governmental agencies in the United States and Europe. He is currently serving as an associate editor of a new journal, Frontiers in Integrative Physiology.
