Integrated Physiology

This series is dedicated to the functions of the body at multiple levels including molecular, cellular, organ, and systems. Understanding the processes that occur at each level (as well as homeostasis, integration, and pathophysiology) is necessary to understand function in health…and dysfunction in disease. Each state-of-the-art title is written by leading experts in their fields and are published as “stand-alone” books. The series is edited by D. Neil Granger, PhD (LSU Health Sciences Center) and Joey P. Granger, PhD (University of Mississippi Medical Center).

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	Lung Endothelium Mary I. Townsley, Troy Stevens Pulmonary endothelium forms the inner lining of blood vessels, where it interprets the complex mechanical and chemical environment within the circulation and adjusts its behavior to facilitate vascular homeostasis. Although endothelium fulfills many … Publication Date: September, 2015 Read More
	Renal Medullary Circulation Allen W. Cowley, Jr., Louise C. Evans The two kidneys of mammalian organisms receive around 25% of the cardiac output at rest, of which only ~7% is distributed to the renal medulla. Despite the low blood flow to the renal medulla, small changes in perfusion to the region can have profoun… Publication Date: August, 2015 Read More
	Genetics of Hypertension Xi Cheng, Bina Joe Hypertension, or elevated blood pressure, is a major risk factor for various cardiovascular, renal diseases, and stroke. The form of hypertension with no identifiable cause is referred to as Essential Hypertension. Familial studies indicate that Esse… Publication Date: August, 2015 Read More
	The Renin-Angiotensin System and the Kidney Xiao C. Li, Jia L. Zhou The renin-angiotensin system (RAS) is one of the most important endocrine (tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) humoral systems in the regulation of blood pressure, cardiovascular, and kidney function in … Publication Date: March, 2015 Read More
	Nitric Oxide in the Kidney Jennifer M. Sasser Nitric oxide (NO) is a key regulator of various cellular signaling pathways throughout the body and plays an important role in renal function under normal physiological and pathophysiological conditions. NO plays a major role in the regulation of ren… Publication Date: April, 2015 Read More
	Pathophysiology of Heat Stroke Lisa R. Leon This book outlines current research efforts that are focused on identifying better diagnostic and prognostic biomarkers of organ injury due to heat illnesses such as heat exhaustion, heat injury, and heat stroke. The purpose of the research is to i… Publication Date: May, 2015 Read More
	Sex and Gender Differences in Cardiovascular-Renal Diseases and Hypertension Jane Reckelhoff Many of the mechanisms responsible for cardiovascular disease and hypertension are well known, and gender is an independent risk factor in many cohorts. How gender contributes to cardiovascular disease has not been completely elucidated. Even in norm… Publication Date: 11/01/2014 Read More
	Gastrointestinal Mucosal Defense System Peter R. Kvietys, Ahmed Yaqinuddin, Wael Al Kattan The gastrointestinal mucosal defense system serves to minimize mucosal injury by either ingested or endogenously produced noxious substances. The mucosal defense system is stratified into pre-epithelial (alkaline mucus), epithelial (dynamic epithelia… Publication Date: 10/01/2014 Read More
	Multiple Sclerosis Alireza Minagar Multiple sclerosis [MS] is one of the most common auto-immune-mediated diseases of the human central nervous system [CNS] which affects young adults and usually causes significant neurological disability. Currently, the causes of MS are still unclear… Publication Date: 09/01/2014 Read More
	Pathogenesis of Atherosclerosis A. Wayne Orr, Arif Yurdagul Jr., Brijesh M. Patel The circulatory system provides the tissues of the body with oxygen and nutrients for survival, allows for the dissemination of inflammatory cells, and clears metabolic waste from building up and damaging tissue. Atherosclerotic disease, the build-up… Publication Date: 06/01/2014 Read More
	Control of Breathing During Exercise Susan A. Ward The control of breathing during exercise remains the source of considerable debate. Classical schemes of the exercise hyperpnea have incorporated elements of proportional feed-back from chemoreceptor sites (carotid body and brainstem) and feed-forwar… Publication Date: 06/01/2014 Read More
	Coronary Circulation Johnathan D. Tune The coronary circulation is unique in that it is responsible for maintaining adequate oxygen and substrate delivery to the organ that generates the pressure needed to drive blood throughout the entire circulatory system. In the simplest terms, corona… Publication Date: 06/01/2014 Read More
	Erectile Dysfunction Rany Shamloul, Anthony J Bella The understanding of the pathophysiology of erectile dysfunction (ED) has advanced significantly over the past two decades. In this ebook, we provide an in-depth analysis of the current knowledge of the pathophysiology of ED in order to provide the r… Publication Date: 03/01/2014 Read More
	Short Bowel Syndrome in Childhood Michael E. Hollwarth Extensive loss of small bowel in all age groups has dramatic consequences on the lifestyle of the patient and the whole family and is accompanied by significant morbidity and mortality. All patients need nutritional and medical support and some of t… Publication Date: 03/01/2014 Read More
	Dengue Rafael Elias Marques, Rodrigo Guabiraba, Daniel Cisalpino, Mauro M. Teixeira, Danielle G. Souza Dengue is a major public health concern throughout the tropical and sub-tropical regions of the world. It is the most rapidly spreading mosquito-borne viral disease, with a 30-fold increase in global incidence over the past 50 years. Infection with a… Publication Date: 02/01/2014 Read More
	Necrotizing Enterocolitis Michael Caplan Necrotizing enterocolitis is an acute inflammatory necrosis of bowel that primarily afflicts premature infants in the neonatal intensive care unit setting. Although patients who develop this disease have high morbidity and mortality rates, the pathog… Publication Date: 12/01/2013 Read More
	Acute Respiratory Distress Syndrome Donna Carden, Marie Elie The acute respiratory distress syndrome (ARDS) is a complex disorder associated with rapidly progressive lung inflammation, non-cardiogenic pulmonary edema, hypoxemic respiratory failure and one or more well-defined risk factors including sepsis and … Publication Date: 10/01/2013 Read More
	Malaria Erika Martins Braga, Juliana Carvalho-Tavares This ebook describes the pathogenesis of malaria and the major consequences of the parasitism to the vertebrate host. Malaria is one of the oldest infectious diseases of mankind, which still exerts a high burden on human health and society. It is cau… Publication Date: 09/01/2013 Read More
	Immune Mechanisms of Hypertension Michael J. Ryan In the vast majority of patients, hypertension has no identifiable cause. Moreover, despite decades of discovery and therapeutic development, approximately only half of the hypertensive patients are achieving clinically recommended blood pressure con… Publication Date: 09/01/2013 Read More
	Cell Survival Programs and Ischemia/Reperfusion Maike Krenz, Christopher Baines, Theodore Kalogeris, Ronald J. Korthuis The major purpose of this book is to review the evidence supporting the concept that intrinsic cell survival programs can be activated by a variety of mildly noxious stimuli or pharmacologic agents to confer protection against the deleterious effects… Publication Date: 09/01/2013 Read More

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