Biologically Active Peptides in Invertebrates

Biologically Active Peptides in Invertebrates
Discovery and Functional Studies

Qing Yu, Zhidan Liang, Chuanzi OuYang, Lingjun Li
ISBN: 9781615044962 | PDF ISBN: 9781615044979
Copyright © 2015 | 182 Pages | Publication Date: September, 2015

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Animal behaviors and emotions are fine-tuned via signal transmission and communication between cells. The nervous system gives instructions and transmits signals to different parts of an organism to produce coordinated activities. Neurons are core components of the nervous system and they use various chemical messengers to communicate with one another. Neuropeptides (NPs), which are small chains of amino acids, represent the largest class of signaling molecules. Since NPs are directly involved in modulating many physiological processes, such as metabolism, reproduction, learning, memory, and social behaviors - there is a growing interest in studying their structures, functions, and distributions. This book aims to summarize advances in invertebrate NP studies concerning molecular diversities, distributions, and biological functions. In addition, the emerging mass spectrometric techniques have been discussed extensively as a powerful tool enabling accelerated invertebrate NP studies.

Table of Contents

Acknowledgments
Overview of Neuropeptides
Mass-Spectrometry (MS)-Based Techniques Enabling Neuropeptide Discovery
Major Classes of Invertebrate Neuropeptides
Concluding Remarks
References
Author Biographies

About the Author(s)

Qing Yu, School of Pharmacy and Department of Chemistry, University of Wisconsin-Madison
Qing Yu is a graduate student in the Pharmaceutical Sciences Division at the University of Wisconsin-Madison. He graduated from Tianjin University in China with a B.S. in Pharmaceutical Sciences in 2012. His research efforts in Professor Lingjun Li's laboratory include the development of novel mass spectrometry-based techniques, especially liquid chromatography coupled with mass spectrometry, for biological applications such as the study of proteomic and peptidomic changes in model organisms induced by physiological manipulations.

Zhidan Liang, School of Pharmacy and Department of Chemistry, University of Wisconsin-Madison
Zhidan Liang is a graduate student in the Pharmaceutical Sciences Division of School of Pharmacy at the University of Wisconsin-Madison. She received her B.S. and M.S in medicinal chemistry from
Tianjin University, China in 2008 and 2010, respectively. Her research in Dr. Lingjun Li's laboratory focuses on developing mass spectrometry-based strategies to study endogenous neuropeptides, especially secreted neuropeptides, by coupling in vivo microdialysis with mass spectrometry.

Chuanzi OuYang, School of Pharmacy and Department of Chemistry, University of Wisconsin-Madison
Chuanzi OuYang is a graduate student in the Department of Chemistry at the University of Wisconsin-Madison. She graduated from University of Science and Technology of China with a B.S. in Chemistry in 2007. After that, she went to graduate school at Virginia Tech for three years before transferring to UW-Madison in 2010. Her graduate research in Professor Lingjun Li's lab has been focusing on the comparative characterization of the nervous systems of decapod crustaceans utilizing various mass spectrometric platforms to investigate the biological functions of small molecules and neuropeptides. She is also highly interested in the development of novel methodologies for mass spectrometry imaging
studies.

Lingjun Li, School of Pharmacy and Department of Chemistry, University of Wisconsin-Madison
Lingjun Li, Ph.D., is a Vilas Distinguished Achievement Professor of Pharmaceutical Sciences and Chemistry at the University of Wisconsin-Madison. She received her B.E. degree in Environmental Analytical Chemistry from Beijing University of Technology, and her Ph.D. in Analytical Chemistry from the University of Illinois at Urbana-Champaign in 2000 under Jonathan Sweedler. She then did postdoctoral work with Richard Smith at PNNL and Eve Marder at Brandeis University prior to starting her independent career in December 2002. Her lab focuses on the development of novel mass spectrometry (MS)-based tools including new isotopic and isobaric labeling strategies that enable hyperplexing for quantitative proteomics, microscale separations, microdialysis and imaging MS for functional discovery of neuropeptides and protein biomarkers in neurodegenerative diseases. Professor Li and her group discovered more than 300 novel neuropeptides in various model organisms. These findings significantly expanded our knowledge about neuropeptides in these important model organisms and transformed our current understanding of neuropeptide family organization. Her lab also explores the novel use of ion mobility MS to address several remaining technical challenges in peptidomic research. Dr. Li has published over 170 peer-reviewed papers, and received numerous awards including ASMS Research Award, NSF CAREER Award, Sloan Fellowship, PittCon Achievement Award, and 2014 ASMS Biemann Medal. Dr. Li has served as a panelist for over 30 federal grant review panels and has just completed her 4-year term on the NIH Enabling Bioanalytical and Imaging Technologies (EBIT) review panel. She is an Associate Editor for the RSC journal Analytical Methods and serves on the Editorial Board for the Journal of the American Society for Mass Spectrometry. Dr. Li serves as a Proteomics Section editor for the journal Frontiers in Biology. She has served on the ASMS Education Committee and the ASMS Asilomar Conference Committee. Dr. Li was elected to the Board of Directors for the US Human Proteome Organization (US HUPO), and is currently the President of the Chinese American Society for Mass Spectrometry.

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