Introduction to Quantitative Cell Biology

Introduction to Quantitative Cell Biology

Wallace F. Marshall
ISBN: 9781615046683 | PDF ISBN: 9781615046690
Hardcover ISBN:9781615047703
Copyright © 2017 | 50 Pages | Publication Date: July, 2017

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For the past decade or more, much of cell biology research has been focused on determining the key molecules involved in different cellular processes, an analytical problem that has been amenable to biochemical and genetic approaches. Now, we face an integrative problem of understanding how all of these molecules work together to produce living cells, a challenge that requires using quantitative approaches to model the complex interactions within a cell, and testing those models with careful quantitative measurements.

This book is an introductory overview of the various approaches, methods, techniques, and models employed in quantitative cell biology, which are reviewed in greater detail in the other volumes in this book series. Particular emphasis is placed on the goals and purpose of quantitative analysis and modeling, and the special challenges that cell biology holds for understanding life at the physical level.

Table of Contents

Overview: What Is Quantitative Cell Biology?
Quantifying Data
Building and Using Models
Examples of Quantitative Cell Biology
Frontiers in Quantitative Cell Biology
How to Get Started in Quantitative Cell Biology
References
Author Biography

About the Author(s)

Wallace F. Marshall, University of California San Francisco
Dr. Wallace F. Marshall is Professor of Biochemistry and Biophysics at the University of California San Francisco and founding director of the NSF-funded Center for Cellular Construction at UCSF. Dr. Marshall's research focuses on understanding how the complex geometry of cells arises from the interplay of molecular and physical mechanisms, as well as how cell geometry relates to cell function. His laboratory has a particular interest in the mechanisms that control the size of organelles. Questions of cell geometry are inherently quantitative, and Dr. Marshall's group employs an integrated combination of quantitative microscopy, image analysis, and computational modeling, together with genetic and biochemical methods. Dr. Marshall received bachelor degrees in Electrical Engineering and Biochemistry at the State University of New York, Stony Brook, and his Ph.D. in Biochemistry at the University of California San Francisco. After postdoctoral training at Yale University in the Molecular, Cellular, and Developmental Biology department, he returned to UCSF in 2003 to start his faculty position. He was an organizer of the Cold Spring Harbor Computational Cell Biology conference, and for the past four years has been organizing a series of meetings and workshops on Quantitative Cell Biology funded by the National Science Foundation. He is also currently co-director of the Physiology Course at the Marine Biological Laboratory in Woods Hole, MA.

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