by Dr Sanjeev Kumar Gupta - All India Institute of Medical Sciences
This book reviews the complex topic of molecular genetics of alpha and beta thalassemia syndromes in a very lucid style. The intricate mechanisms responsible for the vast genetic as well as phenotypic heterogeneity of thalassemia syndromes have been divided in sub-sections for a better understanding and clinical correlation. The authors have also briefly touched upon the issues of laboratory confirmation of these disorders as well as their preventive strategies.
The quality of the book has been enhanced by the efficient use of schematic diagrams, tables and pictures of a range of molecular tests performed in clinical cases. It provides an overview of the latest molecular diagnostic approach to thalassemia syndromes; however the details of the molecular techniques have not been included, probably due to the short-format of the book. So, the readers will get an overview of the topic in this book and can be used as a supplement to the other available detailed reference books. The vast clinical experience of the authors has enriched the content of the book with the common mutations detected in the Indian sub-continent being highlighted. This book will be useful for trainee students, research scholars and practicing Pathologists, especially Hematopathologists; as well as Clinical Hematologists; Pediatricians; Medical Geneticists and Molecular Biologists.