Stem Cells and Extracellular Matrices

Stem Cells and Extracellular Matrices

Lakshmi Kiran Chelluri
ISBN: 9781615043767 | PDF ISBN: 9781615043774
Copyright © 2012 | 84 Pages | Publication Date: 03/01/2012

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Stem cells have great potential in regenerative medicine and tissue injury. Regulation of stem cell homeostasis in a 3D microenvironment is controlled by the niche components that influence stem cell fate, regulation, and function. It is therefore necessary to understand the mechanisms of cell-cell interaction, molecular cross talk between stem cells and their extracellular matrix (ECM) environment. The adhesion molecules play a pivotal role in establishing the cell-cell contact and subsequent integration with the ECM. This understanding is the basis for establishing design criteria for biomimetic. The integrated approach by biologists, material science engineers, biomedical engineers, and clinicians is the key in the development of tissue engineered constructs for effective translation to clinics.

Table of Contents

Abbreviations
Introduction to Stem Cell Biology and Niche Components
ECM - Structure and Organization
ECM Control, Regulation on Stem Cell Fate and Function
ECM and Stem Cell Cultures
Acknowledgments
Bibliography
Author Biography
Titles of Related Interest

About the Author(s)

Lakshmi Kiran Chelluri, Department of Transplant Biology, Immunology & Stem Cell Lab, Global Hospitals, Lakdi-ka-Pool, Hyderabad, India
Dr. Lakshmi Kiran Chelluri is currently the Head of the Department of Transplant Biology, Immunology & Stem Cell Lab at Global Hospitals, Lakdi-ka-Pool, Hyderabad, India. In 1993, she graduated in Pharmacy from Birla Institute of Technology & Science, Pilani. She was awarded a Ph.D. in Immunogenetics (1999), working with the late Prof. K.J.R. Murthy at Mahavir Hospital & Research Centre. She was awarded the young scientist fellowship (BOYSCAST) by the Department of Science & Technology; GoI. She was key investigator to government funded grants at Global Hospitals. Her research is focused on transdifferentiating the rodent bone marrow allogeneic mesenchymal stem cells to insulin secreting beta islets and nano-encapsulate them for the long-term insulin therapy for the treatment of Type-I diabetes. She was instrumental in carrying out the registered investigator initiated clinical trials in Cardiovascular Diseases (Dilated Cardiomyopathy; Scarred / Injured Myocardium: Myocardial Infarcts), Spinal Cord Injuries. She has a keen interest in the development of novel nano-biomaterial, with mesenchymal stem cells in treating intervertebral disc degeneration in an injectable form, the issues of real-time visualization of the stem cells in a primate model tagging with nanoprobes, with bio-compatible surface modifications. She has published about 40 peer reviewed papers. She is currently holding the post of Regional Secretary for the International Society for Cellular Therapy (ISCT)-Asia beginning June 2011 to May 2014.

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