Neuropeptide Receptors

Neuropeptide Receptors

Ivone Gomes, Jonathan Wardman, Steve Stockton, Lakshmi A. Devi
ISBN: 9781615044689 | PDF ISBN: 9781615044696
Copyright © 2013 | 167 Pages | Publication Date: 05/01/2013

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Neuropeptides mediate their effects by binding and activating receptors that are responsible for converting these extracellular stimuli into intracellular responses. Most neuropeptides interact with G protein-coupled receptors that transduce the signal by activating heterotrimeric G proteins leading to alterations in second messenger systems to amplify the signal and elicit the intracellular response. In this review, we describe the general structure of G protein-coupled receptors including the information obtained from crystal structure determination that has given an insight into the activation mechanism of these receptors. In addition, we summarize the components of the signal transduction system (including G proteins, effectors and second messengers generally activated by the neuropeptide receptors). Using select examples of neuropeptide-receptor systems, we highlight the neuropeptides and corresponding receptors involved in modulation of pain and analgesia, body weight regulation, and hormonal regulation. Finally, we discuss the enzyme-linked tyrosine kinase receptors activated by growth factors and discuss the emerging concepts in targeting neuropeptide receptors for the identification of novel therapeutics targeting these systems.

Table of Contents

Abbreviations
Overview of Neuropeptide Receptors
G Protein-Coupled Receptors: General Structure & Function
G Protein-Coupled Receptor Signaling
Neuropeptide Processing and Regulation
Neuropeptide Receptors
Perspectives
References

About the Author(s)

Ivone Gomes, Departments of Pharmacology and Systems Therapeutics, Psychiatry and Neuroscience and The Friedman Brain Institute, Mount Sinai School of Medicine

Jonathan Wardman, Departments of Pharmacology and Systems Therapeutics, Psychiatry and Neuroscience and The Friedman Brain Institute, Mount Sinai School of Medicine

Steve Stockton, Departments of Pharmacology and Systems Therapeutics, Psychiatry and Neuroscience and The Friedman Brain Institute, Mount Sinai School of Medicine

Lakshmi A. Devi, Department of Pharmacology and Systems Therapeutics, Department of Neuroscience, Department of Psychiatry, Mount Sinai School of Medicine

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