Pathogenesis of Atherosclerosis

Pathogenesis of Atherosclerosis

From Cell Biology to Therapeutics

A. Wayne Orr, Arif Yurdagul Jr., Brijesh M. Patel
ISBN: 9781615046560 | PDF ISBN: 9781615046577
Copyright © 2014 | 125 Pages | Publication Date: 06/01/2014

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The circulatory system provides the tissues of the body with oxygen and nutrients for survival, allows for the dissemination of inflammatory cells, and clears metabolic waste from building up and damaging tissue. Atherosclerotic disease, the build-up of fat, inflammatory cells, and fibrotic tissue in the vessel wall, hinders this function, resulting in inadequate perfusion of the target tissue. Hypoxia, or lack of oxygen, rapidly results in cellular dysfunction that profoundly affects the functionality of the overall tissue. Atherosclerosis-associated tissue ischemia and hypoxia because of loss of blood flow underlies several significant disease pathologies including ischemic heart disease, stroke, and peripheral artery disease. In this eBook, we examine the process of atherosclerotic plaque formation both at the cellular level and the level of clinical presentation. Through this book, we hope to impart to the reader a better understanding of how vessel structure, environmental risk factors, and genetic predisposition contribute to atherosclerotic disease and how current and future therapies seek to circumvent the cellular processes contributing to plaque formation to reduce atherosclerotic plaque burden and clinical complications.

Table of Contents

List of Videos
Introduction to Atherosclerosis
Endothelial Cell Activation and Arterial Hemodynamics
Cholesterol and Cardiovascular Disease
Inflammation in Atherosclerosis
Smooth Muscle Cells and Plaque Vulnerability
Diagnosing Atherosclerotic Disease
Treatment and Prevention
Summary and Future Perspectives
Author Biographies

About the Author(s)

A. Wayne Orr, Departments of Pathology and Cell Biology and Anatomy LSU Health Sciences Center
A. Wayne Orr received his Ph.D. in Cellular and Molecular Pathology from the University of Alabama in Birmingham in 2002, followed by post-doctoral training in the Cardiovascular Research Center at the University of Virginia. In 2007, Dr. Orr joined the faculty of the Louisiana State University Health Sciences Center in Shreveport (LSUHSC-S). Dr. Orr's research focuses on cardiovascular cell biology and its role in atherosclerotic plaque formation. He serves on grant review sections and holds or has held committee appointments with the American Heart Association, the American Diabetes Association, and the North American Vascular Biology Organization.

Arif Yurdagul Jr., Departments of Pathology and Cell Biology and Anatomy LSU Health Sciences Center
Arif Yurdagul Jr. received his B.S. degree in Biology from Louisiana Tech University in 2008. After graduation, Arif spent 3 years working as a Research Associate in the Department of Pathology and is currently working toward a Ph.D. in the Department of Cell Biology and Anatomy at LSUHSC-S. Mr. Yurdagul has published eight manuscripts in the field of cardiovascular cell biology, and his graduate work currently receives funding from the American Heart Association and the Interdisciplinary Toxicology Program at LSUHSC-S.

Brijesh M. Patel, Department of Medicine Division of Cardiology LSU Health Sciences Center
Brijesh Patel received his Bachelor of Medicine and Surgery from the Baroda Medical College in Gujarat, India. Following residency and a Cardiovascular Fellowship at Rutgers/University of Medicine and Dentistry New Jersey Medical School, Dr. Patel joined the faculty of the Department of Medicine, Division of Cardiology at LSUHSC-S. He currently serves as the Director of the Coronary Care Unit and Associate Director for the Cardiovascular Fellowship Program at LSUHSC-S. Dr. Patel received numerous honors and awards for his research during residency and fellowship training and has published five manuscripts on cardiovascular disease.

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