Vesicular Transport in the Secretory and Endocytic Pathways

Vesicular Transport in the Secretory and Endocytic Pathways

Anne Muesch
ISBN: 9781615046584 | PDF ISBN: 9781615046591
Copyright © 2014 | 125 Pages | Publication Date: 11/01/2014

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The concept of vesicular traffic as a means of protein transport in and out of cells and between membrane compartments has been established since the 1960s. Its basic principles are beautifully simple, yet the details of protein transport are complex enough to find novel classes of transport vesicles, and trafficking itineraries still being described to date. In this treatise, the reader will be introduced to mechanisms of vesicle sculpting, cargo selection, vesicle targeting, and vesicle consumption that have emerged as common characteristics of multiple transport steps in the exocytic and endocytic pathways. These fundamentals also reveal the basis for the specificity and selectivity of individual transport steps. We will further discuss how protein transport might lead to the establishment and maintenance of the endomembrane system of eukaryotic cells. The concepts for these mechanisms are based on experimental evidence combined with mathematical modeling that can disclose the minimal requirements for the generation of the distinct membrane compartments.

Table of Contents

Compartmentalization Is a Hallmark of Eukaryotic Cells
Organelles Can Be Classified Based on Their Origin
There Are Multiple Entry Points Into the Endomembrane System and a Network of Connecting Trafficking Routes
There Are Exceptions and Extensions to the Classic Trafficking Itineraries
A Mathematical Model Can Explain How Organelle Size Is Established and Maintained
Coats and SNAREs Constitute the Core Machinery for Vesicle Budding and Fusion
A Mathematical Model Explains How Coats and SNAREs Are Sufficient to Generate Organelle Identity
How Vesicle Formation Is Linked to Cargo Incorporation
RabGTPases Are the Master Regulators of Vesicular Traffic
The Mechanisms and Physiological Roles of Endocytosis
Models for Protein Transport in the Golgi Apparatus
Summary
Acknowledgments
References
Author Biography

About the Author(s)

Anne Muesch, Department of Developmental & Molecular Biology Albert Einstein College of Medicine
Anne Muesch obtained her B.Sc. in Genetics from Martin-Luther University Halle/Wittenberg, and her Ph.D. in Cell Biology from Humboldt University, Berlin, Germany. She conducted her thesis research in the laboratory of Tom Rapoport on the characterization of the protein translocation machinery in yeast and obtained post-doctoral training in epithelial cell biology in the group of Enrique Rodriguez-Boulan at Cornell Medical College New York. As a postdoctoral associate, Dr. Muesch elucidated mechanisms of apical and basolateral protein sorting in the biosynthetic pathway of epithelial cells. Although the work of her own research group at Albert-Einstein College of Medicine in the Bronx, NY, is focused on the characterization of polarity determinants and signaling pathways for the establishment and maintenance of epithelial cell polarity, she has also maintained an interest in questions of protein trafficking. As part of her larger quest to understand how columnar and hepatocyte epithelia establish their distinct polarity phenotypes, her group investigates the molecular basis for the different trafficking itineraries that apical proteins take in kidney-derived and hepatocyte-derived epithelial cells.

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