Vascular Biology of the Placenta, 2nd Edition

Vascular Biology of the Placenta, 2nd Edition

Yuping Wang
ISBN: 9781615047505 | PDF ISBN: 9781615047512
Copyright © 2017 | 114 Pages | Publication Date: June, 2017

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The placenta is an organ that connects the developing fetus to the uterine wall, thereby allowing nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.

The placenta is literally the "tree of life." Structurally, the placenta is a hemochorial villous organ. Functionally, it is highly complex machinery: (1) it acts like a lung in the exchange of oxygen and carbon dioxide; (2) it works as a digestive system, absorbing all necessary nutrients for fetal development and growth; (3) it functions as a kidney to remove wastes; and (4) it behaves as an immune barrier that protects the growing fetus from antigen attack from the maternal system. The placenta is also an important endocrine organ producing many hormones and growth factors that regulate the course of pregnancy, support and promote fetal growth, and initiate parturition.

HOWEVER, ALL THESE TASKS DEPEND ON NORMAL VASCULAR DEVELOPMENT WITHIN THE PLACENTA ITSELF.

This book has collected and updated available information on current understanding of the vascular function in the human placenta.

Table of Contents

Introduction
Placental Blood Circulation
Structure of the Placenta
Cell Types of the Placenta
Oxygen Tension and Placental Vascular Development
Vasculogenesis and Angiogenesis of Human Placenta
Angiogenic Factors
Vasoactivators and Placental Vasoactivity
Trophoblast-Derived Extracellular Vesicles
Placenta-Derived MicroRNAs and Immune Response in Pregnancy
Lymphatic Phenotypic Characteristics of the Human Placenta
Placental Tissue and Cord Blood Stem Cells
Summary
Acknowledgments
References
Author Biography

About the Author(s)

Yuping Wang, Louisiana State University Health Sciences Center, Shreveport
Dr. Yuping Wang is a Professor in the Department of Obstetrics and Gynecology and the Department of Cellular and Molecular Physiology at Louisiana State University Health Sciences Center-Shreveport (LSUHSC-Shreveport), Louisiana. She received her M.D. degree in medicine from Harbin Medical University, China, in 1980 and her Ph.D. degree in physiology from Medical College of Virginia, Virginia Commonwealth University, Virginia, USA, in 1994. In 1997, Dr. Wang joined the faculty of LSUHSC-Shreveport, Department of Obstetrics and Gynecology. Her major research fields are placental and endothelial function in pregnancy and pregnancy complications such as preeclampsia. She is a member of several scientific societies including the Society for Reproductive Investigation, the International Society for the Study of Hypertension in Pregnancy, Perinatal Research Society, and the American Physiological Society. Dr. Wang has received a number of grants including National Institutes of Health, NICHD, and NHLBI and served as a standing member of the NIH pregnancy and perinatology study section. She also serves on the editorial board of the International Journal of Reproductive Medicine. Dr. Wang is a co-author of over 120 publications on original research or reviews in the field of placenta, trophoblast and endothelial function, kidney injury in pregnancy, and preeclampsia.

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