Protein Activation & Cancer

SERIES EDITOR:
A. Majid Khatib, INSERM and University of Bordeaux
This series is designed to summarize all aspects of protein maturation by proprotein convertases in cancer. Topics included deal with the importance of these processes in the acquisition of malignant phenotypes by tumor cells, induction of tumor growth, and metastasis. This series also provides the latest knowledge on the clinical significance of convertase expression and activity, and the maturation of their protein substrates in various cancers. The potential use of their inhibition as a therapeutic approach is also explored.

ISSN (print): 2169-9399 / ISSN (electronic): 2169-9410

Editor Bios


Processing of VEGF-C and -Dby the Proprotein Convertases Processing of VEGF-C and -Dby the Proprotein Convertases
Geraldine Siegfried, Abdel-Majid Khatib
The vascular endothelial growth factor (VEGF) family members that include VEGF-A, -B, -C, -D, and placental growth factor (PlGF), display distinct binding affinities for their receptors VEGFR-1, -2, and/or -3. In addition to their requirements in the...
Publication Date: 11/01/2013

Read More


Therapeutic Potential of Furin Inhibition Therapeutic Potential of Furin Inhibition
Jeroen Declercq, J.W.M. Creemers
The proprotein convertase Furin is a serine endoprotease which cleaves protein precursors carboxyterminal of basic residues in motifs such as Arg-X-X-Arg and Lys/Arg-Arg. Cleavage usually results in activation of the proprotein but can also inactivat...
Publication Date: 11/01/2012

Read More


The Role of Proprotein Convertases in Animal Models of Skin Carcinogenesis The Role of Proprotein Convertases in Animal Models of Skin Carcinogenesis
Daniel Bassi, Jian Fu, Jirong Zhang, Andres J.P. Klein-Szanto
Many proprotein convertases (PC), especially furin and PACE4, are involved in pathological processes such as viral infection, inflammation, hypercholesterolemia, and cancer, and have been postulated as therapeutic targets for some of these diseases. ...
Publication Date: 07/01/2012

Read More


Proprotein Convertases in Gynecological Cancers Proprotein Convertases in Gynecological Cancers
Andres J.P. Klein-Szanto, Jirong Zhang, Daniel Bassi
Gynecological cancers include neoplasias of internal female genital organs, mainly ovarian, endometrial and cervical tumors, and cancers of the external female genital structures. Current scientific evidence indicates that both up- and down-regulatio...
Publication Date: 08/01/2012

Read More


The Proprotein Convertases The Proprotein Convertases
Abdel-Majid Khatib
Proprotein convertases (PCs) are a family of proteases including PC1, PC2, Furin, PC4, PACE4, PC5, and PC7. These enzymes are involved in the maturation of many precursor proteins involved in the process of tumorigenesis and metastasis. Since their d...
Publication Date: 02/01/2013

Read More


Non-peptide Inhibitors of Proprotein Convertase Subtilisin Kexins (PCSKs) Non-peptide Inhibitors of Proprotein Convertase Subtilisin Kexins (PCSKs)
Utpal Chandra De, Priyambada Mishra, Prasenjit Rudra Pal
The Ca+2-dependent mammalian Proprotein Convertase Subtilisin Kexins (PCSKs) or Proprotein/ Prohormone Convertases (PCs) are a family of endoproteases that play critical roles not only in normal development and metabolism but also in various physiolo...
Publication Date: 09/01/2012

Read More



Result Pages:  1  Displaying 1 to 6 (of 6 products)
Browse by Subject
Case Studies in Engineering
ACM Books
IOP Concise Physics
0 items
LATEST NEWS

Newsletter
Note: Registered customers go to: Your Account to subscribe.

E-Mail Address:

Your Name: