Integrated Physiology

Physiology is a scientific discipline devoted to understanding the functions of the body. It addresses function at multiple levels, including molecular, cellular, organ, and system. An appreciation of the processes that occur at each level is necessary to understand function in health and the dysfunction associated with disease. Homeostasis and integration are fundamental principles of physiology that account for the relative constancy of organ processes and bodily function even in the face of substantial environmental changes. This constancy results from integrative, cooperative interactions of chemical and electrical signaling processes within and between cells, organs and systems. This series on the broad field of physiology covers the major organ systems from an integrative perspective that addresses the molecular and cellular processes that contribute to homeostasis. Material on pathophysiology is also included throughout the books. These state-of-the-art treatises were produced by leading experts in the field of physiology. Each book includes stand-alone information and is intended to be of value to students, scientists, and clinicians in the biomedical sciences. Since physiological concepts are an ever-changing work-in-progress, each contributor will have the opportunity to make periodic updates of the covered material.

Editor Bios


Multiple Sclerosis Multiple Sclerosis
Alireza Minagar
Multiple sclerosis [MS] is one of the most common auto-immune-mediated diseases of the human central nervous system [CNS] which affects young adults and usually causes significant neurological disability. Currently, the causes of MS are still unclear...
Publication Date: 09/01/2014

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Pathogenesis of Atherosclerosis Pathogenesis of Atherosclerosis
A. Wayne Orr, Arif Yurdagul Jr., Brijesh M. Patel
The circulatory system provides the tissues of the body with oxygen and nutrients for survival, allows for the dissemination of inflammatory cells, and clears metabolic waste from building up and damaging tissue. Atherosclerotic disease, the build-up...
Publication Date: 06/01/2014

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Control of Breathing During Exercise Control of Breathing During Exercise
Susan A. Ward
The control of breathing during exercise remains the source of considerable debate. Classical schemes of the exercise hyperpnea have incorporated elements of proportional feed-back from chemoreceptor sites (carotid body and brainstem) and feed-forwar...
Publication Date: 06/01/2014

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Coronary Circulation Coronary Circulation
Johnathan D. Tune
The coronary circulation is unique in that it is responsible for maintaining adequate oxygen and substrate delivery to the organ that generates the pressure needed to drive blood throughout the entire circulatory system. In the simplest terms, corona...
Publication Date: 06/01/2014

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Erectile Dysfunction Erectile Dysfunction
Rany Shamloul, Anthony J Bella
The understanding of the pathophysiology of erectile dysfunction (ED) has advanced significantly over the past two decades. In this ebook, we provide an in-depth analysis of the current knowledge of the pathophysiology of ED in order to provide the r...
Publication Date: 03/01/2014

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Short Bowel Syndrome in Childhood Short Bowel Syndrome in Childhood
Michael E. Hollwarth
Extensive loss of small bowel in all age groups has dramatic consequences on the lifestyle of the patient and the whole family and is accompanied by significant morbidity and mortality. All patients need nutritional and medical support and some of t...
Publication Date: 03/01/2014

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Dengue Dengue
Rafael Elias Marques, Rodrigo Guabiraba, Daniel Cisalpino, Mauro M. Teixeira, Danielle G. Souza
Dengue is a major public health concern throughout the tropical and sub-tropical regions of the world. It is the most rapidly spreading mosquito-borne viral disease, with a 30-fold increase in global incidence over the past 50 years. Infection with a...
Publication Date: 02/01/2014

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Necrotizing Enterocolitis Necrotizing Enterocolitis
Michael Caplan
Necrotizing enterocolitis is an acute inflammatory necrosis of bowel that primarily afflicts premature infants in the neonatal intensive care unit setting. Although patients who develop this disease have high morbidity and mortality rates, the pathog...
Publication Date: 12/01/2013

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Acute Respiratory Distress Syndrome Acute Respiratory Distress Syndrome
Donna Carden, Marie Elie
The acute respiratory distress syndrome (ARDS) is a complex disorder associated with rapidly progressive lung inflammation, non-cardiogenic pulmonary edema, hypoxemic respiratory failure and one or more well-defined risk factors including sepsis and ...
Publication Date: 10/01/2013

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Malaria Malaria
Erika Martins Braga, Juliana Carvalho-Tavares
This ebook describes the pathogenesis of malaria and the major consequences of the parasitism to the vertebrate host. Malaria is one of the oldest infectious diseases of mankind, which still exerts a high burden on human health and society. It is cau...
Publication Date: 09/01/2013

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Immune Mechanisms of Hypertension Immune Mechanisms of Hypertension
Michael J. Ryan
In the vast majority of patients, hypertension has no identifiable cause. Moreover, despite decades of discovery and therapeutic development, approximately only half of the hypertensive patients are achieving clinically recommended blood pressure con...
Publication Date: 09/01/2013

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Cell Survival Programs and Ischemia/Reperfusion Cell Survival Programs and Ischemia/Reperfusion
Maike Krenz, Christopher Baines, Theodore Kalogeris, Ronald J. Korthuis
The major purpose of this book is to review the evidence supporting the concept that intrinsic cell survival programs can be activated by a variety of mildly noxious stimuli or pharmacologic agents to confer protection against the deleterious effects...
Publication Date: 09/01/2013

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Control of Potassium
David B. Young
Several physiological mechanisms act to regulate renal potassium excretion and distribution. Together they comprise an integrated control system that may be envisioned as being made up of several interacting negative feedback control mechanisms, all ...
Publication Date: 08/01/2013

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Stroke Stroke
Jens Minnerup, Antje Schmidt, Christiane Albert-Weissenberger, Christoph Kleinschnitz
Stroke is a major global health problem because of its large contribution to mortality, morbidity, and disability. The most common form of stroke is ischemic stroke which accounts for approximately 80% of all strokes. During the past decade, our know...
Publication Date: 08/01/2013

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Pulmonary Gas Exchange Pulmonary Gas Exchange
G. Kim Prisk, Susan R. Hopkins
The lung receives the entire cardiac output from the right heart and must load oxygen onto and unload carbon dioxide from perfusing blood in the correct amounts to meet the metabolic needs of the body. It does so through the process of passive diffus...
Publication Date: 08/01/2013

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Developmental Programming of Cardiovascular Disease Developmental Programming of Cardiovascular Disease
Barbara T. Alexander
Numerous epidemiological studies report that birth weight is inversely associated with blood pressure, suggesting that slow growth during fetal life programs hypertension and increased risk for cardiovascular disease in later life. Different experime...
Publication Date: 06/01/2013

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Peripheral Arterial Disease Peripheral Arterial Disease
Christopher G. Kevil, Shyamal C. Bir, Christopher B. Pattillo
Peripheral arterial disease (PAD) is a cardiovascular disorder of the peripheral vasculature due to progressive atherosclerotic stenosis of conduit arteries restricting blood flow to tissues. PAD is typically a disease of older individuals, and the i...
Publication Date: 08/01/2013

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Ascites Ascites
Jens Henriksen, Soren Moller
This volume deals with the history, aetiology, pathophysiology, symptoms, signs, prognosis, and rational treatment of ascites. During the past decade, our knowledge of the pathophysiology of ascites has increased substantially and more specific thera...
Publication Date: 06/01/2013

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Respiratory Muscles Respiratory Muscles
Gary C. Sieck, Heather M. Gransee
Breathing is usually automatic and without conscious effort; yet our breathing is a complex motor function requiring the coordinated activation of a number of respiratory muscles that span from our heads to our abdomen. Some of our respiratory muscle...
Publication Date: 05/01/2012

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Local Control of Microvascular Perfusion Local Control of Microvascular Perfusion
Michael Hill, Michael Davis
Local control of microvascular perfusion refers to the ability of individual tissues to maintain a relative constancy of hemodynamics in the face of changing perfusion pressure while meeting metabolic demands appropriately. The regulation of local bl...
Publication Date: 10/01/2012

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