Integrated Physiology

Physiology is a scientific discipline devoted to understanding the functions of the body. It addresses function at multiple levels, including molecular, cellular, organ, and system. An appreciation of the processes that occur at each level is necessary to understand function in health and the dysfunction associated with disease. Homeostasis and integration are fundamental principles of physiology that account for the relative constancy of organ processes and bodily function even in the face of substantial environmental changes. This constancy results from integrative, cooperative interactions of chemical and electrical signaling processes within and between cells, organs and systems. This series on the broad field of physiology covers the major organ systems from an integrative perspective that addresses the molecular and cellular processes that contribute to homeostasis. Material on pathophysiology is also included throughout the books. These state-of-the-art treatises were produced by leading experts in the field of physiology. Each book includes stand-alone information and is intended to be of value to students, scientists, and clinicians in the biomedical sciences. Since physiological concepts are an ever-changing work-in-progress, each contributor will have the opportunity to make periodic updates of the covered material.

Editor Bios


The Endocannabinoid System in Local and Systemic Inflammation The Endocannabinoid System in Local and Systemic Inflammation
Melanie E.M. Kelly, Christian Lehmann, Juan Zhou
This book focuses on the role of the endocannabinoid system in local and systemic inflammation, with individual chapters written by experts in the field of cannabinoid research and medicine. The topics explore the actions of the endocannabinoid syste...
Publication Date: March, 2017

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Polycystic Kidney Disease Polycystic Kidney Disease
Cristian Riella, Peter G. Czarnecki, Theodore I. Steinman
This book reviews important aspects of polycystic kidney diseases, the latest scientific understanding of the diseases and syndromes, along with the therapies being developed. Cystic kidney diseases comprise a spectrum of genetic syndromes defined by...
Publication Date: January, 2017

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The Blood-Brain Barrier in Health and Disease The Blood-Brain Barrier in Health and Disease
William G. Mayhan, Denise M. Arrick
The blood-brain barrier (BBB) is a complex and dynamic structure that protects the brain from cells within the vasculature, from the immune system and from pathogens. This barrier is present in arterioles, capillaries and venules and is formed at the...
Publication Date: December, 2016

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The Biliary System, 2nd Edition The Biliary System, 2nd Edition
David Q.-H. Wang, Brent A. Neuschwander-Tetri, Piero Portincasa
The biliary system is a complex network of microscopic and macroscopic structures involved in the formation of bile, an aqueous fluid in which a considerable amount of otherwise immiscible cholesterol is transported by other lipids such as bile acids...
Publication Date: December, 2016

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Cardiovascular Responses to Exercise, Second Edition Cardiovascular Responses to Exercise, Second Edition
Lusha Xiang, Robert L. Hester
Exercise is the act of increasing metabolic rate for the purpose of enhancing physical fitness. Exercise can be one of the most stressful physiological responses that the body undertakes. With exercise, there are increases in metabolic rate, heart ra...
Publication Date: December, 2016

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Regulation of Gastrointestinal Mucosal Growth, Second Edition Regulation of Gastrointestinal Mucosal Growth, Second Edition
Rao N. Jaladanki, Jian-Ying Wang
The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastroint...
Publication Date: November, 2016

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Molecular Mechanisms of Body Water Homeostasis Molecular Mechanisms of Body Water Homeostasis
Carolyn M. Ecelbarger, Dharmendra Kumar Chaudhary, Hwal Lee, Swasti Tiwari
This book discusses our intimate relationship with and dependence on water, how the body regulates its water levels, and various pathophysiological states associated with impairments in body water homeostasis. The human body consists of 70-80% water....
Publication Date: November, 2016

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Vascular Smooth Muscle Function in Hypertension Vascular Smooth Muscle Function in Hypertension
Theodora Szasz, Rita C.A. Tostes
Hypertension is defined by an increase in systemic blood pressure above limits considered normal, currently set at 140 mmHg for systolic and 90 mmHg for diastolic pressure. Assuming central venous pressure to be near zero, mean arterial pressure is d...
Publication Date: October, 2016

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Regulation of Tissue Oxygenation, Second Edition Regulation of Tissue Oxygenation, Second Edition
Roland Pittman
This book describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory ...
Publication Date: August, 2016

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The Cerebral Circulation, Second Edition The Cerebral Circulation, Second Edition
Marilyn J. Cipolla
This book reviews special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high meta...
Publication Date: July, 2016

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Lung Endothelium Lung Endothelium
Mary I. Townsley, Troy Stevens
Pulmonary endothelium forms the inner lining of blood vessels, where it interprets the complex mechanical and chemical environment within the circulation and adjusts its behavior to facilitate vascular homeostasis. Although endothelium fulfills many ...
Publication Date: September, 2015

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Renal Medullary Circulation Renal Medullary Circulation
Allen W. Cowley, Jr., Louise C. Evans
The two kidneys of mammalian organisms receive around 25% of the cardiac output at rest, of which only ~7% is distributed to the renal medulla. Despite the low blood flow to the renal medulla, small changes in perfusion to the region can have profoun...
Publication Date: August, 2015

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Genetics of Hypertension Genetics of Hypertension
Xi Cheng, Bina Joe
Hypertension, or elevated blood pressure, is a major risk factor for various cardiovascular, renal diseases, and stroke. The form of hypertension with no identifiable cause is referred to as Essential Hypertension. Familial studies indicate that Esse...
Publication Date: August, 2015

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The Renin-Angiotensin System and the Kidney The Renin-Angiotensin System and the Kidney
Xiao C. Li, Jia L. Zhou
The renin-angiotensin system (RAS) is one of the most important endocrine (tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) humoral systems in the regulation of blood pressure, cardiovascular, and kidney function in ...
Publication Date: March, 2015

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Nitric Oxide in the Kidney Nitric Oxide in the Kidney
Jennifer M. Sasser
Nitric oxide (NO) is a key regulator of various cellular signaling pathways throughout the body and plays an important role in renal function under normal physiological and pathophysiological conditions. NO plays a major role in the regulation of ren...
Publication Date: April, 2015

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Pathophysiology of Heat Stroke Pathophysiology of Heat Stroke
Lisa R. Leon
This book outlines current research efforts that are focused on identifying better diagnostic and prognostic biomarkers of organ injury due to heat illnesses such as heat exhaustion, heat injury, and heat stroke. The purpose of the research is to i...
Publication Date: May, 2015

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Sex and Gender Differences in Cardiovascular-Renal Diseases and Hypertension Sex and Gender Differences in Cardiovascular-Renal Diseases and Hypertension
Jane Reckelhoff
Many of the mechanisms responsible for cardiovascular disease and hypertension are well known, and gender is an independent risk factor in many cohorts. How gender contributes to cardiovascular disease has not been completely elucidated. Even in norm...
Publication Date: 11/01/2014

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Gastrointestinal Mucosal Defense System Gastrointestinal Mucosal Defense System
Peter R. Kvietys, Ahmed Yaqinuddin, Wael Al Kattan
The gastrointestinal mucosal defense system serves to minimize mucosal injury by either ingested or endogenously produced noxious substances. The mucosal defense system is stratified into pre-epithelial (alkaline mucus), epithelial (dynamic epithelia...
Publication Date: 10/01/2014

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Multiple Sclerosis Multiple Sclerosis
Alireza Minagar
Multiple sclerosis [MS] is one of the most common auto-immune-mediated diseases of the human central nervous system [CNS] which affects young adults and usually causes significant neurological disability. Currently, the causes of MS are still unclear...
Publication Date: 09/01/2014

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Pathogenesis of Atherosclerosis Pathogenesis of Atherosclerosis
A. Wayne Orr, Arif Yurdagul Jr., Brijesh M. Patel
The circulatory system provides the tissues of the body with oxygen and nutrients for survival, allows for the dissemination of inflammatory cells, and clears metabolic waste from building up and damaging tissue. Atherosclerotic disease, the build-up...
Publication Date: 06/01/2014

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